// Inicio
1ª Div. EE.UU.
22ª Jornada - 22.10.2021 20:00
| Equipo local | Equipo visitante | Resultado | |
| Terremotos San José | Chicago Fire CF | 2:0 (1:0) | Detalles |
| Galácticos LA | Canarios Columbus | 0:4 (0:4) | Detalles |
| CF Atlanta | Magos Kansas | 1:1 (0:1) | Detalles |
| Halcones Carolina | Dynamo Texas | 3:1 (2:1) | Detalles |
| Revs Foxborough | UD Dallas | 0:2 (0:1) | Detalles |
| Miami FC | Deportivo Salt Lake | 5:0 (3:0) | Detalles |
| CD Charleston | Toros NYC | 1:3 (1:2) | Detalles |
| Chivas EE.UU. | Seattle Sounters | 0:0 (0:0) | Detalles |
| Veloces Colorado | Washington United | 3:0 (2:0) | Detalles |
| Puesto | Equipo | Partidos | Puntos | Potencia | Goles | DG | V | E | D |
| 1 |
Magos Kansas 
|
22 | 56 | 840,61 | 46 : 10 | 36 | 18 | 2 | 2 |
| 2 |
Miami FC
|
22 | 52 | 822,31 | 54 : 19 | 35 | 17 | 1 | 4 |
| 3 |
CF Atlanta (C)
|
22 | 47 | 831,12 | 34 : 17 | 17 | 14 | 5 | 3 |
| 4 |
Halcones Carolina
|
22 | 44 | 800,33 | 44 : 22 | 22 | 13 | 5 | 4 |
| 5 |
Seattle Sounters
|
22 | 42 | 790,78 | 40 : 25 | 15 | 12 | 6 | 4 |
| 6 |
Dynamo Texas
|
22 | 37 | 767,08 | 36 : 27 | 9 | 10 | 7 | 5 |
| 7 |
Chivas EE.UU.
|
22 | 33 | 752,88 | 35 : 23 | 12 | 8 | 9 | 5 |
| 8 |
Terremotos San José
|
22 | 32 | 734,14 | 33 : 29 | 4 | 8 | 8 | 6 |
| 9 |
Canarios Columbus
|
22 | 32 | 732,75 | 34 : 36 | -2 | 9 | 5 | 8 |
| 10 |
UD Dallas
|
22 | 30 | 786,68 | 34 : 26 | 8 | 8 | 6 | 8 |
| 11 |
Revs Foxborough
|
22 | 27 | 722,42 | 31 : 38 | -7 | 8 | 3 | 11 |
| 12 |
Chicago Fire CF
|
22 | 25 | 700,57 | 23 : 28 | -5 | 6 | 7 | 9 |
| 13 |
Veloces Colorado
|
22 | 23 | 737,02 | 33 : 36 | -3 | 5 | 8 | 9 |
| 14 |
Toros NYC
|
22 | 21 | 726,08 | 34 : 51 | -17 | 5 | 6 | 11 |
| 15 |
CD Charleston
|
22 | 21 | 722,84 | 29 : 47 | -18 | 5 | 6 | 11 |
| 16 |
Deportivo Salt Lake
|
22 | 16 | 688,95 | 20 : 43 | -23 | 4 | 4 | 14 |
| 17 |
Galácticos LA
|
22 | 6 | 600,38 | 9 : 52 | -43 | 1 | 3 | 18 |
| 18 |
Washington United
|
22 | 3 | 651,23 | 13 : 53 | -40 | 0 | 3 | 19 |
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